When you first plug in the LocoBuffer-USB it should pop up a little balloon
  that says something like "! Found new hardware  LocoBuffer-USB."
 
  
In
  a few seconds a "Found
  New Hardware Wizard" window opens up. Check the little circle that says "No,
  not this time."

 The "Next" button
  becomes active.  Click "Next". 
  
A window opens up that asks you to put in the driver CD. That is all you need
  to do. Once you load the driver CD it should automatically find the correct
  files and
  go
    on to the next window without the need for checking any boxes, making any
  selections, nor clicking any buttons.

Windows then pops up a warning message from Microsoft about not having passed
  Windows Logo Testing. Not being a corporate supporter of Microsoft, we have
  not paid them to put their logo on our version of the driver, so you will need
  to click on the button that says "Continue Anyway".

It should then
  continue automatically to the point where it says "Completing the Found
  New Hardware Wizard" and
  you can click on "Finish"

As soon as you click "Finish" the computer acts like it hasn't paid any attention to what it just did, so you have to do it all over again. Of course this time the CD is already in the drive, so you just click "Next" at that point. Again tell Windows that this driver will not do any bad things to the system, and it will soon proceed a second time to the last screen where you can click "Finish".
At this point you should have the driver installed such that Windows will
  remember it.

If you unplug the LocoBuffer-USB, Windows should make a "bink-bonk" sound. If you plug it in again it should do a "bonk-bink" sound, but not make you install the drivers again, even if you use a different USB port.
Once you have installed the Windows drivers and have your LocoBuffer-USB connected,
  then you can start up your software. Your software will not load properly until
  after the drivers are installed. Go into the Windows control panel system information
  area, (Start - Control Panel
  -
  System)
  then
  click
  on the Hardware tab and select Device Manager. Open up the Ports section and
  check that the LocoBuffer-USB shows up as an option. If it is not there, it
  didn't install correctly. The COM number shown with the LocoBuffer-USB
  entry is the one
  to use with your software when you set its preferences.